Transcriptomique et épissage dans le cancer
2024
MAJIQlopedia: an encyclopedia of RNA splicing variations in human tissues and cancer. Quesnel-Vallières M, Jewell S, Lynch KW, Thomas-Tikhonenko A, Barash Y Nucleic Acids Research
2023
CHESSBOARD: a Bayesian model for unsupervised detection of alternative splicing based subtypes in heterogeneous cancers. Wang D, Quesnel-Vallières M, Jewell P, Elzubeir M, Lynch KW, Thomas-Tikhonenko A, Barash Y Nature Communications
2022
High-throughput mutagenesis identifies mutations and RNA-binding
proteins controlling CD19 splicing and CART-19 therapy resistance.
Cortés-López M, Schulz L, Enculescu M, Paret C, Spiekermann B, Busch A, Orekhova
A, Kielisch F, Quesnel-Vallières M, Torres-Diz M, Faber J, Barash Y, Thomas-
Tikhonenko A, Zarnack K, Legewie S, König J
Nature Communications
Identifying common transcriptome signatures of cancer by interpreting deep learning
models.
Jha A*#, Quesnel-Vallières M*#, Thomas-Tikhonenko A, Lynch KW, Barash Y#
Genome Biology
* co-premiers auteurs
# auteurs de correspondance
Modulation of CD22 protein expression in childhood
leukemia by pervasive splicing aberrations: implications for CD22-directed
immunotherapies.
Zheng S, Gillespie E, Naqvi A, Hayer K, Ang Z, Torres-Diz M, Quesnel-Vallières M,
Hottman D, Bagashev A, Chukinas J, Asnani M, Shraim R, Schmidt C, Taylor DM,
Rheingold S.R, O’Brien MM, Singh N, Lynch K.W, Ruella M, Barash Y, Tasian SK,
Thomas-Tikhonenko A
Blood Cancer Discovery
2021
Alternative splicing redefines landscape of commonly
mutated genes in acute myeloid leukemia.
Rivera OD, Mallory MJ, Quesnel-Vallières M, Schultz D.C, Carroll M, Barash Y,
Cherry S, Lynch KW
PNAS
Épissage alternatif dans les troubles de l’autisme
2020
Autism-misregulated eIF4G microexons control synaptic translation and higher order
cognitive functions.
Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr
S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, Sharma E, Quesnel-
Vallières M, Permanyer J, Maier S, Georgiou J, Irimia M, Sonenberg N, Forman-Kay
JD, Gingras AC, Collingridge GL, Woodin MA, Cordes SP, Blencowe BJ
Molecular Cell
2019
Autism Spectrum Disorder: Insights into convergent mechanisms from transcriptomics.
Quesnel-Vallières M#, Weatheritt RJ, Cordes SP#, and Blencowe BJ#
Nature Reviews Genetics
# corresponding authors
Article de couverture:
2016
Misregulation of an activity-dependent splicing network as a common mechanism
underlying autism spectrum disorders.
Quesnel-Vallières M, Dargaei Z, Irimia M, Gonatopoulos-Pournatzis T, Ip J, Wu M,
Sterne-Weiler T, Nakagawa S, Woodin MA, Blencowe BJ, and Cordes SP
Molecular Cell
Article couvert par The Globe and Mail:
2015
Essential roles for
the splicing regulator nSR100/SRRM4 during nervous system development.
Quesnel-Vallières M, Irimia M, Cordes SP, and Blencowe BJ
Genes and Development
2014
A highly conserved program of neuronal microexons is misregulated in autistic brains.
Irimia M, Weatheritt RJ, Ellis J, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M,
Quesnel-Vallières M, Tapial J, Raj B, O’Hanlon D, Barrios-Rodiles M, Sternberg MJ,
Cordes SP, Roth FP, Wrana JL, Geschwind DH, and Blencowe BJ
Cell
Article souligné dans un Preview dans Cell, un Editor’s Choice dans Science et un Research Highlights dans Nature Genetics;
couvert part des média internationaux (e.g Toronto Star, The Scientist)
Autres
2023
The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Liu X, Jones WD, Quesnel-Vallières M, Devadiga SA, Lorent K, Valvezan AJ, Myers RL, Li N, Lengner CJ, Barash Y, Pack M, Klein PS. Journal of Developmental Biology
2022
Identification and characterization of RBM12 as a novel
regulator of fetal hemoglobin expression.
Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallières M,
Abdulmalik O, Chou ST, Peslak SA, Khandros E, Keller CA, Giardine BM, Hardison
RC, Shi J, Blobel GA
Blood Advances
2020
Rapid and scalable profiling of nascent RNA with fastGRO.
Barbieri E, Hill C, Quesnel-Vallières M, Zucco AJ, Barash Y, Gardini A
Cell Reports
2019
Missense mutations in NKAP cause a disorder of
transcriptional regulation characterized by marfanoid habitus and cognitive impairment
Fiordaliso SK, Iwata-Otsubo A, Ritter AL, Quesnel-Vallières M, Fujiki K, Nishi E,
Hancarova M, Miyake N, Morton JEV, Lee S, Hackmann K, Bando M, Masuda K,
Nakato R, Arakawa M, Bhoj E, Li D, Hakonarson H, Takeda R, Harr M, Keena B,
Zackai EH, Okamoto N, Mizuno S, Ko JM, Valachova A, Prchalova D, Vlckova M,
Pippucci T, Seiler C, Choi M, Matsumoto N, Di Donato N, Barash Y, Sedlacek Z,
Shirahige K, Izumi K
American Journal of Human Genetics
2017
An atlas of alternative splicing profiles and functional associations reveals new
regulatory programs and genes that simultaneously express multiple major isoforms.
Tapial J, Ha KCH, Sterne-Weiler T, Gohr A, Braunschweig U, Hermoso-Pulido A,
Quesnel-Vallières M, Permanyer J, Sodaei R, Marquez Y, Cozzuto L, Wang X, Gómez-
Velázquez M, Rayon T, Manzanares M, Ponomarenko J, Blencowe BJ, and Irimia M
Genome Research
2012
Seronegative Hepatitis C Virus infection in a child
infected via mother-to-child transmission.
Larouche A, Gaëtan G, El-Bilali N, Quesnel-Vallières M, Martin SR, Alvarez F,
Shoukry NH, and Soudeyns H
Journal of Clinical Microbiology
2011
Novel HIV-1 recombinant
forms in antenatal cohort, Montreal, Quebec, Canada.
Quesnel-Vallières M, Kouzayha I, Tran E, Barry I, Lasgi C, Mérindol N, Monteil V,
Ransy DG, Boucher M, Lapointe N, and Soudeyns H
Emerging Infectious Diseases
2008
HCV
quasispecies evolution during treatment with interferon alfa-2b and ribavirin in two
children coinfected with HCV and HIV-1.
Quesnel-Vallières M, Lemay M, Lapointe N, Martin SR, and Soudeyns H
Journal of Clinical Virology