Interrogating the RNA to find new cancer treatments
Our lab uses high-throughput sequencing data and experimental validations to find RNA variations involved in normal tissue development or in cancer.
Using variations in RNA splicing patterns, it is possible to discover molecular
signals missed with other approaches. Over the years, transcriptomic analyses
have provided key insight on questions encompassing the fields of
autism spectrum disorders and cancer. For example:
- Survey of all alternative splicing events occuring in 86 normal human tissues and 41 cancer datesets - see Quesnel-Vallières et al. 2024
- Discovery of molecular patterns shared by a large array of tumor types and characterized by the deregulation of RNA processing - see Jha, Quesnel-Vallières et al. 2022
- Description of a program of alternative RNA splicing events causally linked to a large fraction of autism spectrum disorder cases - see Irimia et al. 2014, Quesnel-Vallières et al. 2016
Vision
Our research is driven by a combination of computional analyses to generate hypotheses and experimental work to describe biological functions. We believe that studying RNA splicing will uncover new therapeutic avenues for cancer. We also believe that the role of RNA-binding proteins is heavily underestimated in immune cell development and function.
News
03/2025 Sarah joins the lab for a 5-month M1 internship
03/2025 Emma presents a poster at the D2R meeting
02/2025 Our collaborative project with Pr. Lee-Hwa Tai is awarded a CCS-Hecht Foundation DIG
for the development of targeted immunotherapies against cholangiocarcinoma
01/2025 Tony joins the lab for a 4-month COOP internship
10/2024 Nassima and Emma present posters at the RiboClub meeting
09/2024 Léo joins the lab for his grad studies
08/2024 The lab receives a Startup Grant from D2R
04/2024 Mathieu QV is awarded a FRQS J1 career scholarship
01/2024 Virginie is awarded a prestigious NSERC Undergraduate Student Research Award
01/2024 Emma and Nassima join the lab for their grad studies
01/2024 Virginie and Mathieu DB join the lab for a 4-month COOP internship
11/2023 MAJIQlopedia is published in Nucleic Acids Research
11/2023 The lab is awarded the Early Career Researchers Award in Genomics – Human
Health by Génome Québec
09/2023 MQV lab officially opens at Université de Sherbrooke
Funding
The lab is supported by a Next Generation of Scientists Award from the Cancer Research Society, an Early career researchers competition in genomics – human health Award from Génome Québec, a Research Scholars Junior 1 scholarship from FRQS, as well as startup funds from the Université de Sherbrooke and CRCHUS.
